CD109 Antigen (CD109) Antibody
780€ (1 ml)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
CD109 Antigen (CD109) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx171776
tested applications
WB, IHC, IF/ICC
Description
This product is currently in development. The lead time for this product may be several months. Please contact us at
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | CD109 Antigen (CD109) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Purification | Purified by Protein A and Protein G affinity chromatography. |
| Size 1 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Please enquire. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | p180,r150,CPAMD7,Platelet-specific Gov antigen,C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7 |
| Background | Antibody anti-CD109 |
| Status | RUO |
Descripción
CD109 molecule is a glycosylphosphatidylinositol (GPI)-anchored cell surface protein that plays a role in regulating various cellular processes, including immune response and hematopoiesis CD109 is expressed on a variety of cells, including T-cells, endothelial cells, and platelets, and functions as a negative regulator of the transforming growth factor-beta (TGF-β) signaling pathway, which is critical for cell proliferation, differentiation, and immune response modulation By interacting with TGF-β receptors, CD109 modulates TGF-β signaling, potentially inhibiting excessive fibrosis or immune suppression Dysregulation of CD109 expression has been linked to certain cancers, where it can enhance tumor cell survival by suppressing anti-tumor immune responses It is also associated with autoimmune diseases, where its role in immune modulation can influence the development of inflammatory conditions Recent studies have explored CD109 as a potential biomarker for various diseases, including cancer and autoimmune disorders, emphasizing its importance in cellular regulation and immune homeostasis
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