CD109 Antigen (CD109) Antibody
292.5€ (80 µl)
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Name
CD109 Antigen (CD109) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx025814
Tested Applications
ELISA, WB
Description
CD109 is a member of the alpha2-macroglobulin/complement superfamily. The encoded GPI-linked glycoprotein is found on the cell surface of platelets, activated T-cells, and endothelial cells. The protein binds to and negatively regulates signaling of transforming growth factor beta (TGF-beta).
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: CD109 Antigen (CD109) Immunogen: KLH-conjugated synthetic peptide between 82-109 amino acids from the N-terminal region of human CD109. |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 162 kDa |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q6YHK3 |
| Alias | p180,r150,CPAMD7,Platelet-specific Gov antigen,C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7 |
| Background | Antibody anti-CD109 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
CD109 molecule is a glycosylphosphatidylinositol (GPI)-anchored cell surface protein that plays a role in regulating various cellular processes, including immune response and hematopoiesis CD109 is expressed on a variety of cells, including T-cells, endothelial cells, and platelets, and functions as a negative regulator of the transforming growth factor-beta (TGF-β) signaling pathway, which is critical for cell proliferation, differentiation, and immune response modulation By interacting with TGF-β receptors, CD109 modulates TGF-β signaling, potentially inhibiting excessive fibrosis or immune suppression Dysregulation of CD109 expression has been linked to certain cancers, where it can enhance tumor cell survival by suppressing anti-tumor immune responses It is also associated with autoimmune diseases, where its role in immune modulation can influence the development of inflammatory conditions Recent studies have explored CD109 as a potential biomarker for various diseases, including cancer and autoimmune disorders, emphasizing its importance in cellular regulation and immune homeostasis
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