Cation-independent mannose-6-phosphate receptor (IGF2R) Antibody (HRP)

Este producto es parte de IGF2R - insulin like growth factor 2 receptor
Cation-independent mannose-6-phosphate receptor (IGF2R) Antibody (HRP)

Pida mas información

935106861

info@markelab.com

Precio

260€ (50 µl)

Antibody anti-IGF2R

proveedor

Abbexa

reference

abx343582

Tested Applications

ELISA

reactivity

Human

status

RUO

clonality

Polyclonal

Descripción

Cation-independent mannose-6-phosphate receptor (IGF2R) Antibody (HRP) is a Rabbit Polyclonal antibody conjugated to HRP for the detection of Human IGF2R.


Background

The insulin-like growth factor 2 receptor (IGF2R) is a multi-functional transmembrane protein primarily known for binding and internalizing insulin-like growth factor 2 (IGF-2). Unlike the insulin-like growth factor 1 receptor (IGF1R), which signals to promote cell proliferation and survival, IGF2R generally acts to limit the bioavailability of IGF-2 and is therefore considered a negative regulator of growth. IGF2R also binds other ligands, including mannose-6-phosphate-tagged proteins, such as lysosomal enzymes, which it transports from the Golgi to lysosomes. This receptor is widely expressed in mammalian tissues and has important roles in development, cellular signaling, and protein trafficking. IGF2R is unique in its signaling capacity, as it lacks intrinsic tyrosine kinase activity. It operates mainly through ligand sequestration, ligand degradation, and the modulation of signaling pathways indirectly by reducing IGF-2 interactions with IGF1R. IGF2R’s role in growth regulation and its involvement in diseases, particularly cancer, has made it a focal point in biomedical research.

Características del producto

category

Primary Antibodies


clonality

Polyclonal


reactivity

Human


immunogen target

Cation-independent mannose-6-phosphate receptor (IGF2R)


host

Rabbit


isotype

IgG


conjugation

HRP


form

Liquid


tested applications

ELISA


purity

> 95%


purification

Purified by Protein G chromatography.


recommended dilution

Optimal dilutions/concentrations should be determined by the end user.


buffer

0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% glycerol.


size 1

50 µl


size 2

100 µl


size 3

200 µl


size 4

1 ml


storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.


or code

IGF2R


dry ice

No


availability

Shipped within 5-10 working days.


alias

Cation-independent mannose-6-phosphate receptor,MPR1,MPRI,CD222,CIMPR,M6P-R,MPR300,CI-M6PR,MPR 300,CI Man-6-P receptor,300 kDa mannose 6-phosphate receptor,IGF-II receptor


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