Caspase Recruitment Domain-Containing Protein 10 (CARD10) Antibody
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935106861
info@markelab.com
Precio
292.5€ (80 µl)
Antibody anti-CARD10
proveedor
Abbexareference
abx028007Tested Applications
ELISA, WBreactivity
Humanstatus
RUOclonality
PolyclonalDescripción
The caspase recruitment domain (CARD) is a protein module that consists of 6 or 7 antiparallel alpha helices. It participates in apoptosis signaling through highly specific protein-protein homophilic interactions. Like several other CARD proteins, CARD10 belongs to the membrane-associated guanylate kinase (MAGUK) family and activates NF-kappa-B (NFKB; see MIM 164011) through BCL10 (MIM 603517) (Wang et al., 2001 [PubMed 11259443]).
Background
CARD10 is a protein that is part of the caspase recruitment domain (CARD) family. Like other members of this family, it plays a role in mediating immune responses by acting as an adaptor protein in cell signaling pathways. CARD10 is involved in the regulation of the NF-κB pathway, a crucial signaling pathway for immune cell activation, inflammation, and cellular survival. CARD10 is also involved in the regulation of apoptosis, and its function helps maintain immune homeostasis by controlling both cell survival and death. Dysregulation of CARD10 may contribute to various immune-related diseases, including cancers and autoimmune disorders, due to improper regulation of NF-κB and apoptosis. Researchers are investigating how CARD10 could be targeted in therapeutic interventions, especially in diseases characterized by chronic inflammation or immune dysfunction.
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human
immunogen target
Caspase Recruitment Domain-Containing Protein 10 (CARD10)
host
Rabbit
isotype
IgG
conjugation
Unconjugated
form
Liquid
tested applications
ELISA, WB
purification
Purified through a protein A column, followed by peptide affinity purification.
recommended dilution
WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
buffer
PBS containing 0.09% sodium azide.
size 1
80 µl
size 2
400 µl
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
CARD10
dry ice
No
availability
Shipped within 5-10 working days.
alias
CARD-containing MAGUK protein 3, BIMP1, CARMA3, IMD89
uniprot id
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