Caspase Recruitment Domain-Containing Protein 10 (CARD10) Antibody
292.5€ (80 µl)
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935106861
info@markelab.com
name
Caspase Recruitment Domain-Containing Protein 10 (CARD10) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx028007
tested applications
ELISA, WB
Description
The caspase recruitment domain (CARD) is a protein module that consists of 6 or 7 antiparallel alpha helices. It participates in apoptosis signaling through highly specific protein-protein homophilic interactions. Like several other CARD proteins, CARD10 belongs to the membrane-associated guanylate kinase (MAGUK) family and activates NF-kappa-B (NFKB; see MIM 164011) through BCL10 (MIM 603517) (Wang et al., 2001 [PubMed 11259443]).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Caspase Recruitment Domain-Containing Protein 10 (CARD10) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9BWT7 |
| Alias | CARD-containing MAGUK protein 3, BIMP1, CARMA3, IMD89 |
| Background | Antibody anti-CARD10 |
| Status | RUO |
Descripción
CARD10 is a protein that is part of the caspase recruitment domain (CARD) family. Like other members of this family, it plays a role in mediating immune responses by acting as an adaptor protein in cell signaling pathways. CARD10 is involved in the regulation of the NF-κB pathway, a crucial signaling pathway for immune cell activation, inflammation, and cellular survival. CARD10 is also involved in the regulation of apoptosis, and its function helps maintain immune homeostasis by controlling both cell survival and death. Dysregulation of CARD10 may contribute to various immune-related diseases, including cancers and autoimmune disorders, due to improper regulation of NF-κB and apoptosis. Researchers are investigating how CARD10 could be targeted in therapeutic interventions, especially in diseases characterized by chronic inflammation or immune dysfunction.
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