CASP2 And RIPK1 Domain Containing Adaptor With Death Domain Protein (CRADD) Antibody (FITC)
481€ (200 µl)
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Name
CASP2 And RIPK1 Domain Containing Adaptor With Death Domain Protein (CRADD) Antibody (FITC)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx273876
Tested Applications
WB, IHC, IF/ICC
Description
CASP2 And RIPK1 Domain Containing Adaptor With Death Domain Protein (CRADD) Antibody (FITC) is a Rabbit Polyclonal antibody conjugated to FITC against CASP2 And RIPK1 Domain Containing Adaptor With Death Domain Protein (CRADD).
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: CASP2 And RIPK1 Domain Containing Adaptor With Death Domain Protein (CRADD) |
| Host | Rabbit |
| Reactivity | Human |
| Detection Method | Laser Line: 488 Excitation/Emission: 499/515 |
| Recommended Dilution | WB: 0.5-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | FITC |
| Isotype | IgG |
| Purification | Purified by antigen-specific affinity chromatography. |
| Size 1 | 200 µl |
| Size 2 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at 4°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | RAIDD, MRT34,CASP2,RIPK1,CRADD |
| Background | Antibody anti-CRADD |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Death domain-containing protein CRADD, also known as RIP, is involved in mediating cellular responses to stress, particularly in the regulation of apoptosis. It contains a death domain (DD) and serves as a key adaptor protein in the signaling pathways triggered by death receptors. CRADD is known to participate in the formation of the death-inducing signaling complex (DISC) when activated by signals such as tumor necrosis factor (TNF) or Fas ligand (FasL), leading to the activation of caspases and subsequent apoptosis. In addition, CRADD has been implicated in other processes, such as inflammation and neurodegeneration. Its expression and function are tightly regulated and have been linked to both cell survival and death in different contexts.
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