Cartilage Oligomeric Matrix Protein (COMP) Antibody
780€ (1 ml)
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Name
Cartilage Oligomeric Matrix Protein (COMP) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx171593
Tested Applications
WB
Description
This product is currently in development. The lead time for this product may be several months. Please contact us at
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Cartilage Oligomeric Matrix Protein (COMP) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC (Predicted): 5-20 µg/ml, IF/ICC (Predicted): 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Purification | Purified by Protein A and Protein G affinity chromatography. |
| Size 1 | 1 ml |
| Form | Liquid |
| Tested Applications | WB |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Please enquire. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | MED,CTS2,EDM1,EPD1,TSP5,PSACH,THBS5,TSP-5,Thrombospondin-5 |
| Background | Antibody anti-COMP |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
COMP is a non-collagenous extracellular matrix protein primarily expressed in cartilage, tendons, and ligaments where it plays a key role in maintaining tissue structure and mechanical integrity COMP interacts with collagen fibrils and other matrix components to facilitate fibril assembly and stabilize the extracellular matrix COMP also functions as a chaperone during collagen secretion, promoting proper folding and export from chondrocytes Mutations in COMP are associated with skeletal dysplasias such as pseudoachondroplasia and multiple epiphyseal dysplasia, which result in abnormal cartilage development, joint pain, and short stature COMP overexpression has been observed in osteoarthritis and rheumatoid arthritis, where its elevated levels contribute to cartilage degradation and inflammation COMP is also implicated in cardiovascular diseases where it regulates vascular smooth muscle cell function and extracellular matrix remodeling
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