Cartilage Oligomeric Matrix Protein (COMP) Antibody
260€ (50 µl)
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935106861
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name
Cartilage Oligomeric Matrix Protein (COMP) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx214835
tested applications
ELISA, IHC
Description
COMP Antibody is a Rabbit Polyclonal against COMP.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Cartilage Oligomeric Matrix Protein (COMP) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | ELISA: 1/2000 - 1/10000, IHC: 1/100 - 1/300. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P49747 |
| Gene ID | 1311 |
| Alias | MED,CTS2,EDM1,EPD1,TSP5,PSACH,THBS5,TSP-5,Thrombospondin-5 |
| Background | Antibody anti-COMP |
| Status | RUO |
Descripción
COMP is a non-collagenous extracellular matrix protein primarily expressed in cartilage, tendons, and ligaments where it plays a key role in maintaining tissue structure and mechanical integrity COMP interacts with collagen fibrils and other matrix components to facilitate fibril assembly and stabilize the extracellular matrix COMP also functions as a chaperone during collagen secretion, promoting proper folding and export from chondrocytes Mutations in COMP are associated with skeletal dysplasias such as pseudoachondroplasia and multiple epiphyseal dysplasia, which result in abnormal cartilage development, joint pain, and short stature COMP overexpression has been observed in osteoarthritis and rheumatoid arthritis, where its elevated levels contribute to cartilage degradation and inflammation COMP is also implicated in cardiovascular diseases where it regulates vascular smooth muscle cell function and extracellular matrix remodeling
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