Carcinoembryonic Antigen Related Cell Adhesion Molecule 3 (CEACAM3) Antibody (Biotin)
403€ (200 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Carcinoembryonic Antigen Related Cell Adhesion Molecule 3 (CEACAM3) Antibody (Biotin)
category
Primary Antibodies
provider
Abbexa
reference
abx273404
tested applications
WB, IHC, IF/ICC
Description
Carcinoembryonic Antigen Related Cell Adhesion Molecule 3 (CEACAM3) Antibody (Biotin) is a Rabbit Polyclonal antibody conjugated to Biotin against Carcinoembryonic Antigen Related Cell Adhesion Molecule 3 (CEACAM3).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Carcinoembryonic Antigen Related Cell Adhesion Molecule 3 (CEACAM3) |
| Host | Rabbit |
| Reactivity | Rat |
| Recommended Dilution | WB: 0.5-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Biotin |
| Isotype | IgG |
| Purification | Purified by antigen-specific affinity chromatography. |
| Size 1 | 200 µl |
| Size 2 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | CEA,CGM1,W264,W282,CD66D,CGM1a,CGM1,Carcinoembryonic antigen-related cell adhesion molecule 3 |
| Background | Antibody anti-CEACAM3 |
| Status | RUO |
Descripción
CEACAM3, also known as CD66d, is part of the carcinoembryonic antigen-related cell adhesion molecules (CEACAMs), a subgroup within the immunoglobulin superfamily (IgSF). CEACAM3 is primarily expressed on granulocytes, particularly neutrophils, and plays a crucial role in the innate immune response, specifically in defending against bacterial infections. Unlike other CEACAM family members that are primarily involved in cell-cell adhesion and tumor biology, CEACAM3 is highly specialized for recognizing and mediating the phagocytosis of bacteria, particularly pathogenic Neisseria species, Haemophilus influenzae, and Moraxella catarrhalis. CEACAM3 functions as an opsonin-independent phagocytic receptor, enabling neutrophils to directly recognize and engulf bacteria without the need for antibody or complement opsonization. This receptor is a critical component of the host defense system against specific bacterial pathogens that have evolved to exploit CEACAM family proteins to adhere to host cells.
Related Products
anti- CEACAM3-Specific antibody
Ver Producto
Recombinant Human CEACAM3
Ver Producto
Carcinoembryonic Antigen Related Cell Adhesion Molecule 3 (CEACAM3) Antibody
CEACAM3 Antibody is a Rabbit Polyclonal antibody against CEACAM3. This gene encodes a member of the family of carcinoembryonic antigen-related cell adhesion molecules (CEACAMs), which are used by several bacterial pathogens to bind and invade host cells. The encoded transmembrane protein directs phagocytosis of several bacterial species that is dependent on the small GTPase Rac. It is thought to serve an important role in controlling human-specific pathogens by the innate immune system. Alternatively spliced transcript variants have been described.
Ver Producto