anti- CEACAM3-Specific antibody
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935106861
info@markelab.com
name
anti- CEACAM3-Specific antibody
category
Primary Antibodies
provider
FineTest
reference
FNab01578
tested applications
ELISA, IHC
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | carcinoembryonic antigen-related cell adhesion molecule 3 |
| Host | Rabbit |
| Reactivity | human |
| Recommended Dilution | IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P40198 |
| Alias | CEA,CGM1,W264,W282,CD66D,CGM1a,CGM1,Carcinoembryonic antigen-related cell adhesion molecule 3 |
| Background | Antibody anti-CEACAM3 |
| Status | RUO |
| Note | This product is for research use only. |
CEACAM3, also known as CD66d, is part of the carcinoembryonic antigen-related cell adhesion molecules (CEACAMs), a subgroup within the immunoglobulin superfamily (IgSF). CEACAM3 is primarily expressed on granulocytes, particularly neutrophils, and plays a crucial role in the innate immune response, specifically in defending against bacterial infections. Unlike other CEACAM family members that are primarily involved in cell-cell adhesion and tumor biology, CEACAM3 is highly specialized for recognizing and mediating the phagocytosis of bacteria, particularly pathogenic Neisseria species, Haemophilus influenzae, and Moraxella catarrhalis. CEACAM3 functions as an opsonin-independent phagocytic receptor, enabling neutrophils to directly recognize and engulf bacteria without the need for antibody or complement opsonization. This receptor is a critical component of the host defense system against specific bacterial pathogens that have evolved to exploit CEACAM family proteins to adhere to host cells.
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