Carcinoembryonic Antigen Related Cell Adhesion Molecule 3 (CEACAM3) Antibody
299€ (100 µl)
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935106861
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name
Carcinoembryonic Antigen Related Cell Adhesion Molecule 3 (CEACAM3) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx104705
tested applications
WB, IHC, IF/ICC
Description
Polyclonal Antibody to Carcinoembryonic Antigen Related Cell Adhesion Molecule 3 (CEACAM3).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Carcinoembryonic Antigen Related Cell Adhesion Molecule 3 (CEACAM3) |
| Host | Rabbit |
| Reactivity | Rat |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | CEA,CGM1,W264,W282,CD66D,CGM1a,CGM1,Carcinoembryonic antigen-related cell adhesion molecule 3 |
| Background | Antibody anti-CEACAM3 |
| Status | RUO |
Descripción
CEACAM3, also known as CD66d, is part of the carcinoembryonic antigen-related cell adhesion molecules (CEACAMs), a subgroup within the immunoglobulin superfamily (IgSF). CEACAM3 is primarily expressed on granulocytes, particularly neutrophils, and plays a crucial role in the innate immune response, specifically in defending against bacterial infections. Unlike other CEACAM family members that are primarily involved in cell-cell adhesion and tumor biology, CEACAM3 is highly specialized for recognizing and mediating the phagocytosis of bacteria, particularly pathogenic Neisseria species, Haemophilus influenzae, and Moraxella catarrhalis. CEACAM3 functions as an opsonin-independent phagocytic receptor, enabling neutrophils to directly recognize and engulf bacteria without the need for antibody or complement opsonization. This receptor is a critical component of the host defense system against specific bacterial pathogens that have evolved to exploit CEACAM family proteins to adhere to host cells.
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