Cannabinoid Receptor 1, Brain (CNR1) Antibody
299€ (100 µl)
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Name
Cannabinoid Receptor 1, Brain (CNR1) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx130764
Tested Applications
IHC
Description
Cannabinoid Receptor 1, Brain Antibody is a Rabbit Polyclonal against Cannabinoid Receptor 1, Brain.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Cannabinoid Receptor 1, Brain (CNR1) Immunogen: CNR1 (Met1-Gln117) |
| Host | Rabbit |
| Reactivity | Rat |
| Recommended Dilution | WB (Predicted): 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC (Predicted): 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | IHC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P20272 |
| Alias | CNR1,THC receptor,CB-R,Cann6,SKR6R,CB1R,Cann7,CB1, CB1A, CB1K5,CNR |
| Background | Antibody anti-CNR1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Cannabinoid Receptor 1 (CNR1), commonly known as CB1, is one of the two primary receptors of the endocannabinoid system (ECS), a lipid signaling system that regulates homeostasis and diverse physiological processes. CB1 is predominantly expressed in the central nervous system (CNS), including regions like the hippocampus, cerebellum, and basal ganglia, where it modulates synaptic transmission and neuronal activity. CB1 interacts with endocannabinoids like anandamide (AEA) and 2-arachidonoylglycerol (2-AG), as well as exogenous cannabinoids like tetrahydrocannabinol (THC), the psychoactive compound in cannabis. Through this interaction, CB1 plays a key role in regulating pain perception, mood, appetite, memory, and motor control. In the periphery, CB1 expression in tissues such as the liver, adipose tissue, and pancreas contributes to energy metabolism, glucose homeostasis, and lipid storage, linking CB1 to obesity and metabolic disorders. Overactivation of CB1 signaling is associated with conditions like addiction, anxiety, and depression, as well as non-alcoholic fatty liver disease (NAFLD) and insulin resistance. CB1 antagonists, such as rimonabant, have been explored for treating obesity and metabolic syndrome, although their psychiatric side effects limit widespread use. The ECS, particularly CB1, continues to be a focus of intense research for developing safer therapeutics targeting pain, neurological disorders, and psychiatric conditions, including post-traumatic stress disorder (PTSD) and epilepsy.
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