Cannabinoid Receptor 1, Brain / CB1 (CNR1) Antibody
312€ (60 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Cannabinoid Receptor 1, Brain / CB1 (CNR1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx001241
tested applications
WB
Description
Cannabinoid Receptor 1, Brain / CB1 (CNR1) Antibody is a Rabbit Polyclonal antibody against CNR1. This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene. [provided by RefSeq, May 2009].
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Cannabinoid Receptor 1, Brain / CB1 (CNR1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | WB |
| Buffer | PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P21554 |
| Gene ID | 1268 |
| NCBI Accession | NP_001153698.1 |
| OMIM | 114610 |
| Alias | CNR1,THC receptor,CB-R,Cann6,SKR6R,CB1R,Cann7,CB1, CB1A, CB1K5,CNR |
| Background | Antibody anti-CNR1 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
Cannabinoid Receptor 1 (CNR1), commonly known as CB1, is one of the two primary receptors of the endocannabinoid system (ECS), a lipid signaling system that regulates homeostasis and diverse physiological processes. CB1 is predominantly expressed in the central nervous system (CNS), including regions like the hippocampus, cerebellum, and basal ganglia, where it modulates synaptic transmission and neuronal activity. CB1 interacts with endocannabinoids like anandamide (AEA) and 2-arachidonoylglycerol (2-AG), as well as exogenous cannabinoids like tetrahydrocannabinol (THC), the psychoactive compound in cannabis. Through this interaction, CB1 plays a key role in regulating pain perception, mood, appetite, memory, and motor control. In the periphery, CB1 expression in tissues such as the liver, adipose tissue, and pancreas contributes to energy metabolism, glucose homeostasis, and lipid storage, linking CB1 to obesity and metabolic disorders. Overactivation of CB1 signaling is associated with conditions like addiction, anxiety, and depression, as well as non-alcoholic fatty liver disease (NAFLD) and insulin resistance. CB1 antagonists, such as rimonabant, have been explored for treating obesity and metabolic syndrome, although their psychiatric side effects limit widespread use. The ECS, particularly CB1, continues to be a focus of intense research for developing safer therapeutics targeting pain, neurological disorders, and psychiatric conditions, including post-traumatic stress disorder (PTSD) and epilepsy.
Related Products
Human CNR1 (Cannabinoid Receptor 1, Brain) ELISA Kit
Ver Producto
Mouse CNR1 (Cannabinoid Receptor 1, Brain) ELISA Kit
Ver Producto