Canalicular Multispecific Organic Anion Transporter 1 (ABCC2) Antibody
364€ (100 µg)
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935106861
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name
Canalicular Multispecific Organic Anion Transporter 1 (ABCC2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx235310
tested applications
ELISA, WB, IHC
Description
MRP2 Antibody is a Rabbit Polyclonal against MRP2.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Canalicular Multispecific Organic Anion Transporter 1 (ABCC2) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1/500 - 1/2000, IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q92887 |
| Alias | ABC30,CMOAT,DJS,MRP2,cMRP |
| Background | Antibody anti-ABCC2 |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
ABCC2, also known as multidrug resistance-associated protein 2 (MRP2), is an ATP-binding cassette transporter primarily expressed on the apical membrane of hepatocytes, where it plays a vital role in bile secretion and detoxification. ABCC2 mediates the ATP-dependent transport of conjugated bilirubin, xenobiotics, and drug metabolites into bile, contributing to the excretion of potentially harmful compounds. It is also expressed in other tissues, such as the kidney and intestine, where it supports renal and intestinal excretion. Mutations in ABCC2 are associated with Dubin-Johnson syndrome, a rare inherited disorder characterized by impaired bilirubin transport and conjugated hyperbilirubinemia. ABCC2’s role in drug efflux and detoxification makes it a significant player in drug pharmacokinetics, impacting drug absorption, distribution, and elimination.
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