Caldesmon (CALD1) Antibody
195€ (20 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Caldesmon (CALD1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx004107
tested applications
ELISA, WB
Description
Caldesmon (CALD1) Antibody is a Rabbit Polyclonal antibody against Caldesmon (CALD1). This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Caldesmon (CALD1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1 µg/ml, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 20 µl |
| Size 2 | 100 µl |
| Size 3 | 2 × 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q05682 |
| Gene ID | 800 |
| NCBI Accession | NP_004333.1, NM_004342.6, NP_149129.2, NM_033138.3 |
| OMIM | 114213 |
| Alias | CALD1, CDM, H-CAD, HCAD, L-CAD caldesmon |
| Background | Antibody anti-CALD1 |
| Status | RUO |
| Note | Concentration: > 0.2 mg/ml - |
Descripción
CALD1 (Caldesmon 1) is a versatile actin-binding protein predominantly expressed in smooth muscle and non-muscle cells, where it plays a key role in modulating cytoskeletal dynamics and cellular contractility. CALD1 interacts with actin filaments, myosin, tropomyosin, and calmodulin, acting as a regulatory mediator of actomyosin interactions crucial for cellular processes such as contraction, migration, and shape changes. In smooth muscle cells, CALD1 contributes to the regulation of contraction by inhibiting the ATPase activity of myosin in a calcium-calmodulin-dependent manner, thereby modulating muscle tone and elasticity. In non-muscle cells, it is implicated in stabilizing the cytoskeleton and facilitating cell motility, often in response to signaling cascades that control cell migration and adhesion. CALD1 has also been associated with cancer progression, where its expression is frequently altered, contributing to tumor invasiveness and metastasis by influencing cytoskeletal reorganization and cellular dynamics. Its phosphorylation state, regulated by various kinases, fine-tunes its interaction with actin and myosin, enabling precise control over cytoskeletal remodeling. These multifunctional attributes make CALD1 a critical player in maintaining cellular integrity and adaptability across different physiological and pathological contexts.
Related Products
Human CALD(Caldesmon) ELISA Kit
Ver Producto
anti- Caldesmon antibody
Ver Producto