Cadherin 5 (CDH5) Antibody

Name: Cadherin 5 (CDH5) Antibody
Brand: Abbexa
SKU: abx015809
Price: 383.5 EUR
Availability: OnlineOnly

Este producto es parte de CDH5 - cadherin 5

Pida mas información

935106861

info@markelab.com

Precio

383.5€ (100 µl)

Antibody anti-CDH5

proveedor

Abbexa

reference

abx015809

Tested Applications

ELISA, WB, FCM

reactivity

Human, Mouse

status

RUO

clonality

Monoclonal

Descripción

This gene is a classical cadherin from the cadherin superfamily and is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer.The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail.Functioning as a classic cadherin by imparting to cells the ability to adhere in a homophilic manner, the protein may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions.An alternative splice variant has been described but its full length sequence has not been determined.

Background

Cadherin-5 (CDH5), also known as VE-cadherin (vascular endothelial cadherin), is a calcium-dependent adhesion protein primarily found in endothelial cells, which line blood and lymphatic vessels. It plays a critical role in maintaining the integrity and permeability of blood vessels by facilitating cell-cell adhesion between endothelial cells. CDH5 is essential for normal vascular development, and disruptions in its expression or function have been linked to various diseases, including cancer, cardiovascular diseases, and inflammatory conditions. As a classical cadherin, CDH5 belongs to a larger family of transmembrane proteins characterized by their cadherin repeats, which enable homophilic (same-type cell) binding and the formation of stable adherens junctions.

Características del producto

clonality

Monoclonal

reactivity

Human, Mouse

immunogen target

Cadherin 5 (CDH5)

host

Mouse

isotype

IgG1

conjugation

Unconjugated

form

Liquid

tested applications

ELISA, WB, FCM

purification

Unpurified ascites.

recommended dilution

ELISA: 1/10000, WB: 1/500 - 1/2000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user.

buffer

Ascitic fluid containing 0.03% sodium azide.

size 1

100 µl

storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

or code

CDH5

dry ice

availability

Shipped within 5-10 working days.

alias

Cadherin-5,7B4,CD144,7B4 antigen,Vascular endothelial cadherin,VE-cadherin

gene id

https://www.ncbi.nlm.nih.gov/gene/1003

note

Concentration: Not determined. -

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Human CDH5(Cadherin-5) ELISA Kit

proveedor

FineTest

reference

EH0589

reactivity

human

status

RUO

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