C5a Anaphylatoxin Chemotactic Receptor 1 (C5AR1) Antibody

Product specifications

Primary Antibodies

Target: C5a Anaphylatoxin Chemotactic Receptor 1 (C5AR1)
Immunogen: abx616231 - C-Terminus: C-RESKSFTRSTVDT

Goat

Human

Concentration: 0.5 mg/ml

P-ELISA: 1/64000, WB: 0.01-0.03 µg/ml, IHC: 6-8 µg/ml, IF/ICC: 10 µg/ml, FCM: 10 µg/ml. Optimal dilutions/concentrations should be determined by the end user.

Polyclonal

Unconjugated

IgG

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

200 µl

Liquid

P-ELISA, WB, IHC, IF/ICC, FCM

Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin.

Shipped within 5-10 working days.

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

No

728, 113959

NP_001727.1

C5AR1,CD88,C5A,C5AR,C5R1,C5a anaphylatoxin chemotactic receptor,C5a-R,complement C5a receptor,complement component 5a receptor 1

Antibody anti-C5AR1

RUO

THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.

Descripción

C5AR1 is a G protein-coupled receptor (GPCR) that binds C5a, a potent anaphylatoxin generated during complement activation, playing a key role in immune responses and inflammation. C5AR1 is primarily expressed on immune cells, including neutrophils, macrophages, eosinophils, and mast cells, where its activation triggers chemotaxis, degranulation, and the release of pro-inflammatory cytokines. The receptor mediates downstream signaling pathways, such as PI3K/Akt, MAPK, and NF-κB, promoting cell migration, survival, and inflammatory responses. C5AR1 is crucial for host defense, facilitating immune cell recruitment to sites of infection and tissue damage. However, dysregulated C5AR1 signaling contributes to excessive inflammation in diseases such as sepsis, rheumatoid arthritis, and asthma. In cancer, C5AR1 modulates the tumor microenvironment by promoting the recruitment of immunosuppressive myeloid cells, facilitating tumor growth and immune evasion. Additionally, C5AR1 activation has been implicated in neuroinflammation, contributing to neurodegenerative diseases like Alzheimer’s. Therapeutic targeting of C5AR1 with antagonists or inhibitors is being explored to treat inflammatory diseases, autoimmune disorders, and complement-driven cancers, aiming to reduce excessive inflammation and immune dysfunction.

Related Products

C5a Anaphylatoxin Chemotactic Receptor 1 (C5AR1) Peptide

C5a Anaphylatoxin Chemotactic Receptor 1 (C5AR1) Peptide is a synthetic peptide. This peptide is used in the production of

Ver Producto