C-X-C Chemokine Receptor Type 4 (CD184) Antibody (PE / Cyanine 5)
429€ (100 tests)
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Name
C-X-C Chemokine Receptor Type 4 (CD184) Antibody (PE / Cyanine 5)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx347026
Tested Applications
FCM
Description
C-X-C Chemokine Receptor Type 4 (CD184) Antibody (PE / Cyanine 5) is a Mouse Monoclonal against C-X-C Chemokine Receptor Type 4 (CD184).
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: C-X-C Chemokine Receptor Type 4 (CD184) |
| Host | Mouse |
| Reactivity | Human, Monkey |
| Clonality | Monoclonal |
| Conjugation | PE / Cyanine 5 |
| Isotype | IgG2a Kappa |
| Clone ID | B415 |
| Size 1 | 100 tests |
| Tested Applications | FCM |
| Buffer | Stabilizing PBS solution containing 15 mM sodium azide. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store in the dark at 2-8°C. Avoid exposure to light. Do not freeze. |
| Dry Ice | No |
| UniProt ID | P61073 |
| Gene ID | 7852 |
| Alias | CXCR4,CD184,D2S201E,FB22,HM89,HSY3RR,LAP-3,LAP3,LCR1,LESTR,NPY3R,NPYR,NPYRL,NPYY3R,WHIM,WHIMS,WHIMS1,fusin |
| Background | Antibody anti-CXCR4 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
CXCR4 is a widely expressed G protein-coupled receptor that binds stromal cell-derived factor-1 (SDF-1/CXCL12), playing a key role in hematopoiesis, organ development, and immune cell trafficking. It is highly expressed on hematopoietic stem cells, lymphocytes, and endothelial cells. CXCR4 activation triggers pathways such as PI3K/Akt, MAPK, and JAK/STAT, promoting cell survival, migration, and proliferation. In the immune system, CXCR4 guides leukocyte migration to lymphoid tissues and inflammatory sites, facilitating immune surveillance. It is critical for embryonic development, particularly in the nervous, cardiovascular, and hematopoietic systems. In cancer, CXCR4 is overexpressed in many malignancies, including breast, lung, and pancreatic cancers, where it promotes tumor progression, metastasis, and angiogenesis by interacting with the CXCL12 gradient. CXCR4 also enhances the homing of cancer cells to distant organs, such as the bone marrow, contributing to metastasis and therapy resistance. In HIV infection, CXCR4 acts as a co-receptor for viral entry into T cells, playing a role in disease progression to AIDS. Targeting CXCR4 with antagonists like plerixafor is a therapeutic strategy for stem cell mobilization, HIV treatment, and anti-cancer therapy. Dysregulation of CXCR4 signaling is linked to inflammatory diseases, immune deficiencies, and metastatic cancer, highlighting its importance in immune regulation and disease pathogenesis.
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