C-C motif chemokine receptor 9 (CD199) Antibody
312€ (0.1 mg)
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Name
C-C motif chemokine receptor 9 (CD199) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx347198
Tested Applications
FCM
Description
C-C motif chemokine receptor 9 (CD199) Antibody is a Mouse Monoclonal antibody against C-C motif chemokine receptor 9 (CD199).
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: C-C motif chemokine receptor 9 (CD199) Immunogen: CD199 transfected CHO cells |
| Host | Mouse |
| Reactivity | Human |
| Assay Type | Prior to lyophilization: 1 mg/ml |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 Kappa |
| Clone ID | D799 |
| Purification | Purified by protein-A affinity chromatography. |
| Size 1 | 0.1 mg |
| Form | Lyophilized |
| Tested Applications | FCM |
| Buffer | Prior to lyophilization: PBS, pH 7.4 with 15 mM sodium azide. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at 2°C to 8°C upon receipt. Do not freeze. |
| Dry Ice | No |
| UniProt ID | P51686 |
| Gene ID | 10803 |
| Alias | CCR9,C-C motif chemokine receptor 9,CC-CKR-9,CDw199,GPR-9-6,GPR28, |
| Background | Antibody anti-CCR9 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
C-C Chemokine Receptor Type 9 (CCR9) is a G-protein-coupled receptor highly expressed on T lymphocytes within the gut-associated lymphoid tissue (GALT) and plays a critical role in mucosal immunity. CCR9 binds its ligand CCL25 (TECK), which is predominantly expressed in the small intestine, guiding the homing of T cells to the intestinal epithelium. This receptor-ligand interaction is crucial for maintaining intestinal immune surveillance and protecting the gut from pathogens. CCR9 is particularly important for the migration of T-helper 1 (Th1) cells and memory T cells into the small intestine, where they contribute to immune homeostasis. However, CCR9 is also implicated in inflammatory bowel diseases (IBD), such as Crohn's disease and ulcerative colitis, where excessive T-cell migration to the gut exacerbates inflammation and tissue damage. In cancer, CCR9 is overexpressed in certain types of T-cell leukemias and gastrointestinal tumors, where it contributes to tumor growth and metastasis by enhancing immune cell recruitment. CCR9 has also been explored as a potential therapeutic target for intestinal inflammation and gastrointestinal cancers. Blocking CCR9-CCL25 signaling with targeted therapies, such as small-molecule inhibitors, has shown promise in reducing gut inflammation and preventing lymphocyte migration in preclinical and clinical studies. This makes CCR9 a pivotal player in intestinal immunity, chronic inflammation, and tumor biology.
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