C-C Chemokine Receptor Type 9 (CCR9) Antibody
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Description
CCR9 Antibody is a Rabbit Polyclonal against CCR9.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | C-C Chemokine Receptor Type 9 (CCR9) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | ELISA: 1/2000 - 1/5000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P51686 |
| Gene ID | 10803 |
| Alias | CCR9,C-C motif chemokine receptor 9,CC-CKR-9,CDw199,GPR-9-6,GPR28, |
| Background | Antibody anti-CCR9 |
| Status | RUO |
Descripción
C-C Chemokine Receptor Type 9 (CCR9) is a G-protein-coupled receptor highly expressed on T lymphocytes within the gut-associated lymphoid tissue (GALT) and plays a critical role in mucosal immunity. CCR9 binds its ligand CCL25 (TECK), which is predominantly expressed in the small intestine, guiding the homing of T cells to the intestinal epithelium. This receptor-ligand interaction is crucial for maintaining intestinal immune surveillance and protecting the gut from pathogens. CCR9 is particularly important for the migration of T-helper 1 (Th1) cells and memory T cells into the small intestine, where they contribute to immune homeostasis. However, CCR9 is also implicated in inflammatory bowel diseases (IBD), such as Crohn's disease and ulcerative colitis, where excessive T-cell migration to the gut exacerbates inflammation and tissue damage. In cancer, CCR9 is overexpressed in certain types of T-cell leukemias and gastrointestinal tumors, where it contributes to tumor growth and metastasis by enhancing immune cell recruitment. CCR9 has also been explored as a potential therapeutic target for intestinal inflammation and gastrointestinal cancers. Blocking CCR9-CCL25 signaling with targeted therapies, such as small-molecule inhibitors, has shown promise in reducing gut inflammation and preventing lymphocyte migration in preclinical and clinical studies. This makes CCR9 a pivotal player in intestinal immunity, chronic inflammation, and tumor biology.
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C-C Chemokine Receptor Type 9 (CCR9) Antibody
The protein encoded by this gene is a member of the beta chemokine receptor family. It is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are key regulators of the thymocytes migration and maturation in normal and inflammation conditions. The specific ligand of this receptor is CCL25. It has been found that this gene is differentially expressed by T lymphocytes of small intestine and colon, suggested a role in the thymocytes recruitment and development that may permit functional specialization of immune responses in different segment of the gastrointestinal tract. This gene is mapped to the chemokine receptor gene cluster region. Two alternatively spliced transcript variants have been described.
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CCR9 Antibody is a Rabbit Polyclonal against CCR9.
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