C-C Motif Chemokine Receptor 9 (CCR9) Antibody
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Description
C-C Motif Chemokine Receptor 9 (CCR9) Antibody is a Rat Monoclonal antibody against CDw199.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | C-C Motif Chemokine Receptor 9 (CCR9) |
| Host | Rat |
| Reactivity | Mouse |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG2a |
| Purification | Purified |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | FCM |
| Buffer | PBS. Contains sodium azide. |
| Availability | Shipped within 3-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9WUT7 |
| Alias | CCR9,C-C motif chemokine receptor 9,CC-CKR-9,CDw199,GPR-9-6,GPR28, |
| Background | Antibody anti-CCR9 |
| Status | RUO |
| Note | Concentration: 1.0 mg/ml - |
Descripción
C-C Chemokine Receptor Type 9 (CCR9) is a G-protein-coupled receptor highly expressed on T lymphocytes within the gut-associated lymphoid tissue (GALT) and plays a critical role in mucosal immunity. CCR9 binds its ligand CCL25 (TECK), which is predominantly expressed in the small intestine, guiding the homing of T cells to the intestinal epithelium. This receptor-ligand interaction is crucial for maintaining intestinal immune surveillance and protecting the gut from pathogens. CCR9 is particularly important for the migration of T-helper 1 (Th1) cells and memory T cells into the small intestine, where they contribute to immune homeostasis. However, CCR9 is also implicated in inflammatory bowel diseases (IBD), such as Crohn's disease and ulcerative colitis, where excessive T-cell migration to the gut exacerbates inflammation and tissue damage. In cancer, CCR9 is overexpressed in certain types of T-cell leukemias and gastrointestinal tumors, where it contributes to tumor growth and metastasis by enhancing immune cell recruitment. CCR9 has also been explored as a potential therapeutic target for intestinal inflammation and gastrointestinal cancers. Blocking CCR9-CCL25 signaling with targeted therapies, such as small-molecule inhibitors, has shown promise in reducing gut inflammation and preventing lymphocyte migration in preclinical and clinical studies. This makes CCR9 a pivotal player in intestinal immunity, chronic inflammation, and tumor biology.
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