C-C Chemokine Receptor Type 8 (CCR8) Antibody
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Description
C-C Chemokine Receptor Type 8 (CCR8) Antibody is a Recombinant Human Monoclonal antibody for the detection of Human CCR8.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | C-C Chemokine Receptor Type 8 (CCR8) |
| Host | Human |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 Lambda 2 |
| Expression | Recombinant |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | FCM |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P51685 |
| Alias | CCR8,C-C motif chemokine receptor 8,ChemR1,CKR-L1,TER1,GPR-CY6,CC-CKR-8,CCR-8,CDw198,CKRL1,CMKBR8,CMKBRL2,CY6,GPRCY6,TER1 |
| Background | Antibody anti-CCR8 |
| Status | RUO |
Descripción
C-C Chemokine Receptor Type 8 (CCR8) is a G-protein-coupled receptor expressed predominantly on T-helper 2 (Th2) cells, regulatory T cells (Tregs), and subsets of monocytes and dendritic cells. CCR8 interacts primarily with its ligand CCL1, promoting the recruitment and migration of immune cells to inflammatory sites and tissues, particularly in the context of allergic responses and chronic inflammation. CCR8 plays a central role in Th2-mediated immune responses, contributing to diseases such as asthma, atopic dermatitis, and other allergic disorders. In addition, CCR8 is highly expressed on tumor-infiltrating Tregs in the tumor microenvironment, where it fosters immune suppression and allows tumor cells to evade host immunity. Its role in tumor progression and metastasis has made CCR8 an attractive target for cancer immunotherapy. Antibody-based therapies targeting CCR8 are under development to deplete Tregs specifically within tumors, restoring anti-tumor immune responses. CCR8 is also implicated in HIV infection, as it can serve as a co-receptor for the virus, facilitating viral entry into immune cells. Further understanding of CCR8 signaling and its interaction with CCL1 will help develop targeted therapies for allergic diseases, autoimmune conditions, and cancer, making it a versatile and critical player in immune regulation.
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