C-C Chemokine Receptor Type 7 (CCR7) Antibody
52€ (10 µg)
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Name
C-C Chemokine Receptor Type 7 (CCR7) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx015219
Tested Applications
WB, IF/ICC
Description
Rabbit polyclonal antibody against CCR7 protein. Immunogen region is Internal.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: C-C Chemokine Receptor Type 7 (CCR7) Immunogen: The antiserum was produced against synthesized peptide derived from Internal of human CCR7. |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | WB, IF/ICC |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P32248 |
| Alias | CCR7,C-C motif chemokine receptor 7,BLR2,CC-CKR-7,CCR-7,CD197,CDw197,CMKBR7,EBI,1 |
| Background | Antibody anti-CCR7 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
C-C Chemokine Receptor Type 7 (CCR7) is a G-protein-coupled receptor (GPCR) expressed on naïve T cells, central memory T cells, dendritic cells, and B cells, playing a central role in immune surveillance and lymphocyte trafficking. CCR7 interacts with its ligands CCL19 and CCL21, which are expressed in secondary lymphoid organs, such as lymph nodes and spleen. This receptor directs homing of lymphocytes and dendritic cells to the lymph nodes, enabling efficient antigen presentation, T-cell activation, and adaptive immune responses. CCR7 is critical for lymphocyte recirculation, guiding naïve T cells from the bloodstream into the lymph nodes where they encounter antigens presented by dendritic cells. In the context of cancer, CCR7 is overexpressed on tumor cells in cancers like breast cancer, gastric cancer, and chronic lymphocytic leukemia (CLL), facilitating lymph node metastasis through chemotactic signaling. Additionally, CCR7 promotes T-cell positioning within the thymus, playing a key role in T-cell development and immune tolerance. Dysregulation of CCR7 signaling is associated with autoimmune diseases, including rheumatoid arthritis and multiple sclerosis, where improper lymphocyte migration contributes to chronic inflammation. Given its role in immune regulation, CCR7 has emerged as a promising therapeutic target in cancer immunotherapy and autoimmune disease treatment, where modulating its activity could restore immune homeostasis or inhibit metastasis.
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