Breast Cancer Type 1 Susceptibility Protein Phospho-Ser1524 (BRCA1 pS1524) Antibody

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Description
BRCA1 (pS1524) Antibody is a Rabbit Polyclonal against BRCA1 (pS1524).
Documents del producto
Product specifications
Category | Primary Antibodies |
Immunogen Target | Breast Cancer Type 1 Susceptibility Protein Phospho-Ser1524 (BRCA1 pS1524) |
Host | Rabbit |
Reactivity | Human |
Assay Data | Modification: Phosphorylation // Target Modification: Ser1524 |
Recommended Dilution | ELISA: 1/10000, IHC: 1/100 - 1/300. Optimal dilutions/concentrations should be determined by the end user. |
Clonality | Polyclonal |
Conjugation | Unconjugated |
Isotype | IgG |
Purification | Purified by affinity chromatography. |
Size 1 | 50 µg |
Size 2 | 100 µg |
Form | Liquid |
Tested Applications | ELISA, IHC |
Buffer | PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Availability | Shipped within 5-10 working days. |
Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
Dry Ice | No |
UniProt ID | P38398 |
Gene ID | 672 |
Alias | BRCAI,BRCC1,BROVCA1,FANCS IRIS,PNCA4,PPP1R53,PSCP,RNF53,RING finger protein 54 |
Background | Antibody anti-BRCA1 |
Status | RUO |
Descripción
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This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified.
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