Breast Cancer Type 1 Susceptibility Protein Phospho-Ser1524 (BRCA1 pS1524) Antibody

Este producto es parte de BRCA1 DNA repair associated
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221€ (50 µg)

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935106861
info@markelab.com
name
Breast Cancer Type 1 Susceptibility Protein Phospho-Ser1524 (BRCA1 pS1524) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx322871
tested applications
ELISA, IHC

Description

BRCA1 (pS1524) Antibody is a Rabbit Polyclonal against BRCA1 (pS1524).

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
Breast Cancer Type 1 Susceptibility Protein Phospho-Ser1524 (BRCA1 pS1524)
Host
Rabbit
Reactivity
Human
Assay Data
Modification: Phosphorylation // Target Modification: Ser1524
Recommended Dilution
ELISA: 1/10000, IHC: 1/100 - 1/300. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Purified by affinity chromatography.
Size 1
50 µg
Size 2
100 µg
Form
Liquid
Tested Applications
ELISA, IHC
Buffer
PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
P38398
Gene ID
672
Alias
BRCAI,BRCC1,BROVCA1,FANCS IRIS,PNCA4,PPP1R53,PSCP,RNF53,RING finger protein 54
Background
Antibody anti-BRCA1 
Status
RUO

Descripción

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This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified.

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