Breast Cancer Anti-Estrogen Resistance Protein 1 Phospho-Tyr410 (BCAR1 pY410) Antibody
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935106861
info@markelab.com
Precio
52€ (10 µg)
Antibody anti-BCAR1
proveedor
Abbexareference
abx012424Tested Applications
ELISA, WB, IHCreactivity
Human, Mouse, Ratstatus
RUOclonality
PolyclonalDescripción
Rabbit polyclonal antibody against p130 Cas protein. Immunogen region is Internal. Specificity is as follows for the reactive species: H:Y410, M:Y414, R:Y508.
Background
BCAR1, also known as the Breast Cancer Anti-Estrogen Resistance 1 protein, is an important protein involved in the development of resistance to anti-estrogen therapies, such as tamoxifen, used in the treatment of estrogen receptor-positive breast cancer. BCAR1 plays a crucial role in cell signaling pathways that regulate cell survival, proliferation, and resistance to apoptosis. It is often upregulated in breast cancer cells that become resistant to estrogen receptor-targeted therapies. The protein interacts with several other signaling molecules involved in the regulation of cell motility and survival, contributing to the metastatic potential of breast cancer cells. Understanding BCAR1’s role in therapy resistance has significant implications for developing alternative therapeutic strategies for patients with estrogen receptor-positive breast cancer who develop resistance to current treatments.
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human, Mouse, Rat
immunogen target
Breast Cancer Anti-Estrogen Resistance Protein 1 Phospho-Tyr410 (BCAR1 pY410)
host
Rabbit
isotype
IgG
conjugation
Unconjugated
form
Liquid
tested applications
ELISA, WB, IHC
purification
Purified from rabbit antiserum by affinity chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
recommended dilution
WB: 1/500 - 1/3000, IHC: 1/50 - 1/100, ELISA: 1/5000. Optimal dilutions/concentrations should be determined by the end user.
buffer
PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol.
size 1
10 µg
size 2
100 µg
size 3
200 µg
size 4
300 µg
size 5
1 mg
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
BCAR1
dry ice
No
availability
Shipped within 5-10 working days.
alias
BCAR1, CAS, CAS1, CASS1, CRKAS, P130Cas, Cas family scaffolding protein, Cas family scaffold protein, BCAR1 scaffold protein, Cas family member
uniprot id
note
Concentration: 1 mg/ml -
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