BRCA1-A Complex Subunit RAP80 (UIMC1) Antibody
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Description
UIMC1 Antibody is a Rabbit Polyclonal against UIMC1.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | BRCA1-A Complex Subunit RAP80 (UIMC1) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1/200 - 1/1000, IHC: 1/20 - 1/200, IF/ICC: 1/10 - 1/100, IP: 1/200 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q96RL1 |
| Gene ID | 51720 |
| OMIM | 609433 |
| Background | Antibody anti-UIMC1 |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
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UIMC1 antibody
Ubiquitin-binding protein(PubMed:24627472). Specifically recognizes and binds 'Lys-63'-linked ubiquitin(PubMed:19328070, Ref.36). Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks(DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1.
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BRCA1-A Complex Subunit RAP80 (UIMC1) Antibody
UIMC1 Antibody is a Rabbit Polyclonal antibody against UIMC1.
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BRCA1-A Complex Subunit RAP80 (UIMC1) Antibody
Rabbit Polyclonal against the UIMC1 protein.
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