Bombesin Receptor Subtype-3 (BRS3) Antibody
221€ (50 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Bombesin Receptor Subtype-3 (BRS3) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx324793
tested applications
ELISA, WB, IHC, IF/ICC
Description
BRS3 Antibody is a Rabbit Polyclonal against BRS3.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Bombesin Receptor Subtype-3 (BRS3) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/300, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Buffer | PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P32247 |
| Gene ID | 680 |
| Alias | BRS3,BB3 receptor,bb3,bombesin receptor subtype-3, bombesin like receptor 3,BB3R, BBR3 |
| Background | Antibody anti-BRS3 |
| Status | RUO |
Descripción
Bombesin Receptor Subtype 3 (BRS3) is an orphan G-protein-coupled receptor within the bombesin receptor family, though its endogenous ligand remains unidentified. BRS3 is predominantly expressed in the central nervous system, including the hypothalamus, as well as in adipose tissue and certain peripheral organs. BRS3 is primarily involved in energy homeostasis and metabolic regulation, as it modulates thermogenesis, appetite control, and body weight. Activation of BRS3 increases energy expenditure by stimulating pathways in brown adipose tissue, enhancing heat production and combating obesity. In addition to energy regulation, BRS3 influences glucose metabolism and insulin sensitivity, suggesting potential roles in type 2 diabetes treatment. Furthermore, BRS3 signaling regulates blood pressure, contributing to cardiovascular homeostasis. Dysregulation of BRS3 expression has been linked to obesity, metabolic syndrome, and certain cancers, particularly lung cancer and prostate cancer, where it may facilitate tumor proliferation and survival. Given its critical roles in metabolism, thermogenesis, and cancer biology, BRS3 has emerged as a potential therapeutic target for metabolic diseases and oncology. Ongoing studies aim to identify its natural ligand and develop pharmacological agonists or antagonists to exploit its therapeutic potential.
Related Products
Bombesin Receptor Subtype-3 (BRS3) Antibody
Rabbit polyclonal antibody against BRS3 protein. Immunogen region is Internal.
Ver Producto
Bombesin Receptor Subtype-3 (BRS3) Antibody
BRS3 Antibody is a Rabbit Polyclonal against BRS3.
Ver ProductoBombesin Receptor Subtype-3 (BRS3) Antibody
BRS3 Antibody is a Rabbit Polyclonal against BRS3.
Ver Producto