Bok BH3 Domain Antibody
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Description
Bok belongs to the BCL-2 protein family. BCL-2 family members form hetero or homodimers and act as anti and pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains all four BCL-2 like domains (BH1, 2, 3 and 4) and is a pro-apoptotic BCL-2 protein identified in the ovary.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Bok BH3 Domain |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified Rabbit Polyclonal Antibody. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9UMX3 |
| NCBI Accession | NP_115904.1 |
| Alias | Hbok,BOKL,BCL2L9,Bcl-2-like protein 9,Bcl2-L-9,Bcl-2-related ovarian killer protein |
| Background | Antibody anti-BOK |
| Status | RUO |
Descripción
Bcl-2-related ovarian killer protein (BOK) is a pro-apoptotic member of the Bcl-2 family that plays a critical role in mediating apoptosis through mitochondrial pathways BOK induces cell death by interacting with other Bcl-2 family members, promoting mitochondrial outer membrane permeabilization and facilitating the release of apoptotic factors like cytochrome c, which activate caspases and lead to programmed cell death Unlike other Bcl-2 family members, BOK is not regulated by the BH3 domain and has a unique role in apoptosis, particularly in ovarian cells BOK’s expression is tightly controlled in healthy tissues, and its dysregulation has been associated with various cancers, where it can influence tumor cell survival, apoptosis resistance, and cancer progression Additionally, BOK has been implicated in regulating neuronal cell death, and its role in maintaining cellular homeostasis under stress conditions suggests it may be a target for therapeutic strategies aimed at inducing apoptosis in tumor cells or protecting against neurodegeneration
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