BH3 Interacting Domain Death Agonist (Bid) Antibody Pair

1495€ (5 × 96 tests)
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name
BH3 Interacting Domain Death Agonist (Bid) Antibody Pair
category
Antibody Pairs
provider
Abbexa
reference
abx370067
tested applications
ELISA
Description
BH3 Interacting Domain Death Agonist (Bid) Antibody Pair for use in Sandwich ELISA assay development.
Documents del producto
Instrucciones
Data sheet
Product specifications
Category | Antibody Pairs |
Immunogen Target | BH3 Interacting Domain Death Agonist (Bid) |
Reactivity | Rat |
Assay Data | Detection Antibody Biotinilated |
Assay Type | Sandwich |
Recommended Dilution | Dilute the Capture Antibody 125-fold with Coating Buffer. Dilute the Biotin-Conjugated Detection Antibody 200-fold with Detection Antibody Diluent. Optimal dilutions/concentrations should be determined by the end user. |
Size 1 | 5 × 96 tests |
Size 2 | 10 × 96 tests |
Form | Standard: Lyophilized--Liquid (Capture Antibody and Detection Antibody) Reconstitute the standard with Standard Diluent. The volume, and therefore standard concentration, should be determined by the end user. |
Tested Applications | ELISA |
Buffer | The Capture and Detection Antibody both contain 0.1% sodium azide. |
Availability | Please enquire. |
Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
Dry Ice | No |
Alias | p22 BID,FP497 |
Background | Antibody Pair for BID |
Status | RUO |
Note | This antibody pair contains ( 5 x 96 det): Detection: 50 µg Capture: 200 µg Standard: 2 µg This product is for research use only. |
Descripción
BH3-interacting domain death agonist (BID) is a pro-apoptotic member of the Bcl-2 family that plays a crucial role in the mitochondrial pathway of apoptosis BID contains a BH3 domain that enables it to interact with anti-apoptotic Bcl-2 family members, promoting apoptosis in response to various stress signals When activated, BID undergoes proteolytic cleavage, resulting in the generation of a truncated form, tBID, which translocates to the mitochondria and triggers the release of cytochrome c from the mitochondrial membrane This release activates the caspase cascade, leading to cell death BID is critical in the cellular response to DNA damage, oxidative stress, and death receptor signaling It also plays a role in immune cell homeostasis, particularly in regulating the survival of T-cells and the elimination of damaged or infected cells BID’s involvement in apoptosis has made it a significant focus in cancer research, where its activity can be modulated to promote tumor cell death Additionally, BID’s role in maintaining cellular integrity under stress underscores its importance in preventing disease progression and maintaining healthy tissue turnover
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