BH3 Interacting Domain Death Agonist (Bid) Antibody Pair

Este producto es parte de BID - BH3-interacting domain death agonist
Product Graph
1261€ (5 × 96 tests)

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935106861
info@markelab.com
name
BH3 Interacting Domain Death Agonist (Bid) Antibody Pair
category
Antibody Pairs
provider
Abbexa
reference
abx370064
tested applications
ELISA

Description

BH3 Interacting Domain Death Agonist (Bid) Antibody Pair for use in Sandwich ELISA assay development. 

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Antibody Pairs
Immunogen Target
BH3 Interacting Domain Death Agonist (Bid)
Reactivity
Human
Assay Data
Detection Antibody Biotinilated
Assay Type
Sandwich
Recommended Dilution
Dilute the Capture Antibody 125-fold with Coating Buffer.  Dilute the Biotin-Conjugated Detection Antibody 200-fold with Detection Antibody Diluent.  Optimal dilutions/concentrations should be determined by the end user.
Size 1
5 × 96 tests
Size 2
10 × 96 tests
Form
Standard: Lyophilized--Liquid (Capture Antibody and Detection Antibody)
Reconstitute the standard with Standard Diluent. The volume, and therefore standard concentration, should be determined by the end user.
Tested Applications
ELISA
Buffer
The Capture and Detection Antibody both contain 0.1% sodium azide.
Availability
Shipped within 5-20 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
Alias
p22 BID,FP497
Background
Antibody Pair for BID
Status
RUO
Note
This antibody pair contains ( 5 x 96 det):    Detection:  50 µg  Capture:  200 µg  Standard:  2 µg
This product is for research use only.

Descripción

BH3-interacting domain death agonist (BID) is a pro-apoptotic member of the Bcl-2 family that plays a crucial role in the mitochondrial pathway of apoptosis BID contains a BH3 domain that enables it to interact with anti-apoptotic Bcl-2 family members, promoting apoptosis in response to various stress signals When activated, BID undergoes proteolytic cleavage, resulting in the generation of a truncated form, tBID, which translocates to the mitochondria and triggers the release of cytochrome c from the mitochondrial membrane This release activates the caspase cascade, leading to cell death BID is critical in the cellular response to DNA damage, oxidative stress, and death receptor signaling It also plays a role in immune cell homeostasis, particularly in regulating the survival of T-cells and the elimination of damaged or infected cells BID’s involvement in apoptosis has made it a significant focus in cancer research, where its activity can be modulated to promote tumor cell death Additionally, BID’s role in maintaining cellular integrity under stress underscores its importance in preventing disease progression and maintaining healthy tissue turnover

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