BH3-Interacting Domain-Containing Protein 3 (Hrk) Antibody
546€ (100 µg)
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935106861
info@markelab.com
name
BH3-Interacting Domain-Containing Protein 3 (Hrk) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx411864
tested applications
WB
Description
BH3-Interacting Domain-Containing Protein 3 (Hrk) Antibody is a Rabbit Polyclonal antibody against BH3-Interacting Domain-Containing Protein 3 (Hrk).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | BH3-Interacting Domain-Containing Protein 3 (Hrk) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | WB |
| Buffer | PBS. Contains sodium azide. |
| Availability | Shipped within 3-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O00198 |
| Alias | DP5,HARAKIRI,BID3,BH3-interacting domain-containing protein 3,Neuronal death protein DP5 |
| Background | Antibody anti-HRK |
| Status | RUO |
| Note | Concentration: 1.0 mg/ml - |
Descripción
Activator of apoptosis harakiri (HRK) is a pro-apoptotic protein that belongs to the Bcl-2 family of proteins, which regulate cell death by controlling mitochondrial outer membrane permeabilization HRK is involved in initiating apoptosis in response to cellular stress, including DNA damage, oxidative stress, and growth factor deprivation HRK interacts with anti-apoptotic proteins like Bcl-2 and Bcl-xL, promoting the release of apoptotic factors such as cytochrome c from the mitochondria, which activates caspases and leads to programmed cell death HRK is particularly important in neurons and immune cells, where it helps eliminate damaged or unwanted cells during development and in response to injury Dysregulation of HRK has been linked to various diseases, including cancer and neurodegenerative disorders, where loss of HRK expression allows cells to evade apoptosis and proliferate uncontrollably In cancer, HRK’s ability to promote cell death makes it a potential therapeutic target for inducing apoptosis in tumor cells
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