Beta-Adducin (ADD2) Antibody

Background

ADD2 encodes beta-adducin, a component of the adducin protein family that works synergistically with alpha-adducin to regulate actin-spectrin interactions in the cytoskeleton. It is expressed predominantly in erythrocytes and the brain, where it contributes to maintaining the structural integrity of cell membranes and regulating intracellular signaling pathways. In erythrocytes, beta-adducin enhances membrane stability by crosslinking spectrin and actin filaments, ensuring the proper mechanical properties of red blood cells. Beta-adducin has also been implicated in neuronal development, particularly in synapse formation and function. Dysregulation or mutations in ADD2 are linked to neurological disorders, including cognitive impairments, and may exacerbate structural defects in red blood cells, contributing to anemia or other hematological abnormalities.