Beta-Adducin (ADD2) Antibody
312€ (60 µl)
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935106861
info@markelab.com
name
Beta-Adducin (ADD2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx124035
tested applications
WB
Description
ADD2 Antibody is a Rabbit Polyclonal Antibody against ADD2.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Beta-Adducin (ADD2) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1/1000 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | WB |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P35612 |
| Gene ID | 119 |
| NCBI Accession | NP_001171983.1 |
| Alias | ADDB,ADDUCIN 2 |
| Background | Antibody anti-ADD2 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
ADD2 encodes beta-adducin, a component of the adducin protein family that works synergistically with alpha-adducin to regulate actin-spectrin interactions in the cytoskeleton. It is expressed predominantly in erythrocytes and the brain, where it contributes to maintaining the structural integrity of cell membranes and regulating intracellular signaling pathways. In erythrocytes, beta-adducin enhances membrane stability by crosslinking spectrin and actin filaments, ensuring the proper mechanical properties of red blood cells. Beta-adducin has also been implicated in neuronal development, particularly in synapse formation and function. Dysregulation or mutations in ADD2 are linked to neurological disorders, including cognitive impairments, and may exacerbate structural defects in red blood cells, contributing to anemia or other hematological abnormalities.
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