Beta 2 Adrenergic Receptor (ADRB2) Antibody
299€ (100 µl)
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Name
Beta 2 Adrenergic Receptor (ADRB2) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx007595
Tested Applications
WB, IHC, FCM
Description
Beta-2 Adrenergic Receptor (ADRB2) Antibody is a Rabbit Polyclonal antibody against Beta-2 Adrenergic Receptor.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Beta 2 Adrenergic Receptor (ADRB2) Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the C-terminal region of human Beta-2 Adrenergic Receptor. The exact sequence is proprietary. |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat, Cow, Dog, Sheep |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | WB: 1/500 - 1/1000, IHC: 1/100 - 1/200, FCM: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Form | Liquid |
| Tested Applications | WB, IHC, FCM |
| Buffer | 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol and 0.01% sodium azide. |
| Availability | Shipped within 7-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P07550, P18762, P10608 |
| Gene ID | 154, 11555 |
| Alias | ADRB2,ADRB2R,ADRBR,B2AR,Adrb-2,beta 2-AR,Gpcr7,BAR,ARB2 |
| Background | Antibody anti-ADRB2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
The adrenergic receptor beta-2 (ADRB2) is another G-protein-coupled receptor widely distributed in smooth muscle tissues, including the lungs, blood vessels, and uterus. ADRB2 activation by catecholamines induces smooth muscle relaxation through cAMP-mediated pathways, leading to bronchodilation, vasodilation, and uterine relaxation. In the respiratory system, ADRB2 is critical for airway relaxation, making it a primary target for bronchodilators used in asthma and chronic obstructive pulmonary disease (COPD) management. Additionally, ADRB2 plays a role in glycogenolysis in the liver and skeletal muscles, promoting energy mobilization during stress or exercise. Genetic variants in ADRB2, such as Gly16Arg and Gln27Glu, influence receptor sensitivity and have been associated with differential responses to beta-agonists and susceptibility to asthma. Overactivation of ADRB2 can lead to desensitization, reducing therapeutic efficacy over time. Its involvement in multiple physiological processes underscores ADRB2's importance in both metabolic and respiratory regulation.
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