Bcl2-Related protein A1 (BCL2A1) Antibody (HRP)
169€ (20 µg)
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Name
Bcl2-Related protein A1 (BCL2A1) Antibody (HRP)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx314488
Tested Applications
ELISA
Description
BCL2A1 Antibody (HRP) is a Rabbit Polyclonal against BCL2A1 conjugated to HRP.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Bcl2-Related protein A1 (BCL2A1) Immunogen: Recombinant human Bcl-2-related protein A1 protein (1-175AA). |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | HRP |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q16548 |
| Gene ID | 597 |
| NCBI Accession | NP_001108207.1, NM_001114735.1, NP_004040.1, NM_004049.3 |
| OMIM | 601056 |
| Alias | ACC-1,ACC-2,ACC1,ACC2,BCL2L5,BFL1,GRS,HBPA1,Bcl-2-like protein 5,Bcl2-L-5 |
| Background | Antibody anti-BCL2A1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
BCL2 related protein A1 (BCL2A1) is an anti-apoptotic protein belonging to the Bcl-2 family, which plays a pivotal role in regulating apoptosis by inhibiting mitochondrial cell death pathways BCL2A1 functions by preventing the release of pro-apoptotic factors, such as cytochrome c, from mitochondria, thus blocking the activation of caspases and preventing cell death Its expression is often induced under stress conditions, such as oxidative stress and inflammatory stimuli, to protect cells from apoptosis BCL2A1 has been implicated in various cancers, where its overexpression allows tumor cells to evade apoptosis, promoting tumor survival and metastasis Additionally, BCL2A1 has a role in regulating immune cell function, particularly in maintaining the survival of B cells and T cells under stress Dysregulation of BCL2A1 contributes to immune system dysfunction and resistance to chemotherapy in cancer therapy, making it a potential target for therapeutic interventions aimed at promoting cell death in cancer cells
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