BCL2 Like 11 Protein

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Especificaciones del producto

Proteins and Peptides

BCL2L11

E. coli

Activity: Not tested
Sequence Fragment: 1-138 AA.
Tag: N-terminal His tag

Human

Unconjugated

Recombinant

> 80% (SDS-PAGE)

2 µg

10 µg

1 mg

Liquid

SDS-PAGE

20 mM Tris-HCl buffer, pH 8.0, 2 M Urea, 20% glycerol, 5 mM DTT and 300 mM NaCl.

Shipped within 5-10 working days.

Store at 4°C if the entire vial will be used within 2-4 weeks. For long-term storage, store at -20 °C. It is recommended to add a carrier protein (0.1% HSA or BSA) for long-term storage. Avoid repeated freeze/thaw cycles.

No

O43521

BAM,BIM,BOD,Bcl-2-like protein 11,Bcl2-interacting mediator of cell death

Protein BCL2L11

RUO

THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
Concentration: 0.5 mg/ml

Background

BCL2 like 11 (BCL2L11), also known as BIM, is a pro-apoptotic protein belonging to the Bcl-2 family, which regulates cell death by controlling mitochondrial outer membrane permeabilization BCL2L11 plays a central role in initiating apoptosis in response to cellular stress, such as DNA damage, oxidative stress, or growth factor deprivation By promoting the release of pro-apoptotic factors, such as cytochrome c, from the mitochondria, BCL2L11 triggers the activation of caspases, leading to programmed cell death BCL2L11’s activity is tightly regulated by interactions with other Bcl-2 family members, particularly anti-apoptotic proteins like BCL2, which prevent its activation In cancers, BCL2L11 is often downregulated, allowing tumor cells to evade apoptosis and continue to proliferate BCL2L11 is also implicated in immune system regulation, where it controls the survival and activation of immune cells, particularly in T-cell homeostasis Its pro-apoptotic function and regulation of immune responses make BCL2L11 an essential player in maintaining cellular integrity and in controlling the balance between cell survival and death

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