Bcl-2-Related Ovarian Killer Protein (BOK) Antibody
260€ (50 µl)
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Name
Bcl-2-Related Ovarian Killer Protein (BOK) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx241360
Tested Applications
ELISA, IHC
Description
BOK Antibody is a Rabbit Polyclonal against BOK.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Bcl-2-Related Ovarian Killer Protein (BOK) Immunogen: Synthetic peptide corresponding to human BOK (BH3 domain). |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Type | Concentration: 0.9 mg/ml |
| Recommended Dilution | ELISA: 1/2000 - 1/5000, IHC: 1/25 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9UMX3 |
| Gene ID | 666 |
| Alias | Hbok,BOKL,BCL2L9,Bcl-2-like protein 9,Bcl2-L-9,Bcl-2-related ovarian killer protein |
| Background | Antibody anti-BOK |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Bcl-2-related ovarian killer protein (BOK) is a pro-apoptotic member of the Bcl-2 family that plays a critical role in mediating apoptosis through mitochondrial pathways BOK induces cell death by interacting with other Bcl-2 family members, promoting mitochondrial outer membrane permeabilization and facilitating the release of apoptotic factors like cytochrome c, which activate caspases and lead to programmed cell death Unlike other Bcl-2 family members, BOK is not regulated by the BH3 domain and has a unique role in apoptosis, particularly in ovarian cells BOK’s expression is tightly controlled in healthy tissues, and its dysregulation has been associated with various cancers, where it can influence tumor cell survival, apoptosis resistance, and cancer progression Additionally, BOK has been implicated in regulating neuronal cell death, and its role in maintaining cellular homeostasis under stress conditions suggests it may be a target for therapeutic strategies aimed at inducing apoptosis in tumor cells or protecting against neurodegeneration
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