B-Cell Differentiation Antigen CD72 (CD72) Antibody (APC)
689€ (100 tests)
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Name
B-Cell Differentiation Antigen CD72 (CD72) Antibody (APC)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx270617
Tested Applications
FCM
Description
Cluster Of Differentiation 72 (CD72) Antibody (APC) is a Rabbit Polyclonal Antibody conjugated to APC against Cluster Of Differentiation 72 (CD72) for use in flow cytometry.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: B-Cell Differentiation Antigen CD72 (CD72) |
| Host | Rabbit |
| Reactivity | Human |
| Detection Method | Laser Line: 647 Excitation/Emission: 651/660 |
| Recommended Dilution | FCM: 1-5 µl/106 cells. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | APC |
| Isotype | IgG |
| Purification | Purified by antigen-specific affinity chromatography. |
| Size 1 | 100 tests |
| Size 2 | 200 tests |
| Size 3 | 500 tests |
| Form | Liquid |
| Tested Applications | FCM |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Please enquire. |
| Storage | Aliquot and store at 2°C to 8°C upon receipt. Avoid exposure to light. |
| Dry Ice | No |
| Alias | LYB2,CD72b,B-cell differentiation antigen CD72 |
| Background | Antibody anti-CD72 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
CD72 is a type II transmembrane glycoprotein belonging to the C-type lectin superfamily. It is mainly expressed on the surface of B cells, as well as some other immune cells such as dendritic cells. CD72 serves as a negative regulator of B cell receptor (BCR) signaling, modulating immune responses by attenuating excessive B cell activation and preventing autoimmunity. CD72 interacts with protein tyrosine phosphatases, including SHP-1 and SHP-2, through its immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic domain. When activated, CD72 negatively regulates BCR signaling, contributing to the maintenance of immune tolerance and B cell homeostasis. Given its central role in B cell regulation, CD72 is involved in autoimmune diseases, chronic inflammatory conditions, and lymphomas.
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