B-Cell Differentiation Antigen CD72 (CD72) Antibody
195€ (20 µl)
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935106861
info@markelab.com
name
B-Cell Differentiation Antigen CD72 (CD72) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx135850
tested applications
ELISA, WB
Description
CD72 Antibody is a Rabbit Polyclonal against CD72.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | B-Cell Differentiation Antigen CD72 (CD72) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | ELISA: 1 µg/ml, WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 20 µl |
| Size 2 | 100 µl |
| Size 3 | 2 × 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P21854 |
| Gene ID | 971 |
| NCBI Accession | NP_001773.1 |
| Alias | LYB2,CD72b,B-cell differentiation antigen CD72 |
| Background | Antibody anti-CD72 |
| Status | RUO |
| Note | Concentration: > 0.2 mg/ml - |
Descripción
CD72 is a type II transmembrane glycoprotein belonging to the C-type lectin superfamily. It is mainly expressed on the surface of B cells, as well as some other immune cells such as dendritic cells. CD72 serves as a negative regulator of B cell receptor (BCR) signaling, modulating immune responses by attenuating excessive B cell activation and preventing autoimmunity. CD72 interacts with protein tyrosine phosphatases, including SHP-1 and SHP-2, through its immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic domain. When activated, CD72 negatively regulates BCR signaling, contributing to the maintenance of immune tolerance and B cell homeostasis. Given its central role in B cell regulation, CD72 is involved in autoimmune diseases, chronic inflammatory conditions, and lymphomas.
