B-Cell Antigen Receptor Complex-Associated Protein Alpha Chain (CD79A) Antibody

Este producto es parte de CD79A molecule
B-Cell Antigen Receptor Complex-Associated Protein Alpha Chain (CD79A) Antibody

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935106861

info@markelab.com

Precio

350€ (100 µg)

Antibody anti-CD79A

proveedor

Abbexa

reference

abx148556

Tested Applications

ELISA, WB, IHC

reactivity

Human, Mouse, Rat

status

RUO

clonality

Polyclonal

Descripción

B-Cell Antigen Receptor Complex-Associated Protein Alpha Chain (CD79A) Antibody is a Rabbit Polyclonal antibody for the detection of CD79A. Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro-and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells.


Background

CD79A, also known as Ig-alpha, is a protein encoded by the CD79A gene in humans. It is a crucial component of the B cell receptor (BCR) complex, playing a significant role in B cell development, activation, and signaling. The BCR complex is essential for the adaptive immune response, allowing B cells to recognize and respond to specific antigens. CD79A, along with CD79B (Ig-beta), forms the signaling component of the BCR, transmitting signals from the antigen-bound surface immunoglobulin (Ig) to the cell's interior, initiating a cascade of intracellular events leading to B cell activation, proliferation, and differentiation.

Características del producto

category

Primary Antibodies


clonality

Polyclonal


reactivity

Human, Mouse, Rat


immunogen target

B-Cell Antigen Receptor Complex-Associated Protein Alpha Chain (CD79A)


host

Rabbit


conjugation

Unconjugated


form

Liquid


tested applications

ELISA, WB, IHC


purity

≥ 95% (SDS-PAGE)


purification

Purified by immunogen affinity chromatography.


buffer

PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.


size 1

100 µg


storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.


or code

CD79A


dry ice

No


availability

Shipped within 5-12 working days.


alias

IGA,MB1,MB-1,IGAlpha,Ig-alpha,MB-1 membrane glycoprotein,Membrane-bound immunoglobulin-associated protein,Surface IgM-associated protein,B-cell antigen receptor complex-associated protein alpha chain


note

This product is for research use only.


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