Autophagy Related 4C Cysteine Peptidase (ATG4C) Antibody
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding the same protein, have been characterized. [provided by RefSeq].
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Autophagy Related 4C Cysteine Peptidase (ATG4C) |
| Host | Mouse |
| Reactivity | Mouse |
| Recommended Dilution | WB: 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 Kappa |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q96DT6 |
| Alias | APG4-C,APG4C,AUTL1,AUTL3,HsAPG4C |
| Background | Antibody anti-ATG4C |
| Status | RUO |
Descripción
Related Products
ATG4C antibody
Cysteine protease required for the cytoplasm to vacuole transport(Cvt) and autophagy. Is not essential for autophagy development under normal conditions but is required for a proper autophagic response under stressful conditions such as prolonged starvation(By similarity). Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine(PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.
Ver Producto
Recombinant Human ATG4C
Ver Producto
Autophagy Related 4C Cysteine Peptidase (ATG4C) Antibody
ATG4C Antibody is a Rabbit Polyclonal Antibody against ATG4C.
Ver Producto