Aurora Kinase A (AURKA) Antibody
195€ (20 µl)
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935106861
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name
Aurora Kinase A (AURKA) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx001733
tested applications
ELISA, WB, IF/ICC
Description
AURKA Antibody is a Rabbit Polyclonal antibody against AURKA. Aurora A (AIK) is a cell cycle-regulated Ser/Thr protein kinase that is overexpressed in many tumor cell lines. Phosphorylation of Aurora A at Thr288 within the kinase activation loop results in a significant increase in its activity and may target the protein for proteasomal degradation during mitosis. The closely-related kinase Aurora B (AIM1) has been implicated in multiple mitotic events, and siRNA silencing of Aurora B expression results in reduced histone H3 phosphorylation, aberrant chromosome alignment/segregation, and altered survivin localization.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Aurora Kinase A (AURKA) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | ELISA: 1 µg/ml, WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 20 µl |
| Size 2 | 100 µl |
| Size 3 | 2 × 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IF/ICC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O14965 |
| Gene ID | 6790 |
| NCBI Accession | NP_003591.2 |
| OMIM | 603072 |
| Alias | AIK,AIRK1,ARK1,AURA,AYK1,BTAK,Serine/threonine-protein kinase 15 |
| Background | Antibody anti-AURKA |
| Status | RUO |
| Note | Concentration: 7.97 mg/ml - |
Descripción
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