ATP-Dependent Translocase ABCB1 (ABCB1) Antibody

273€ (100 µl)
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935106861
info@markelab.com
name
ATP-Dependent Translocase ABCB1 (ABCB1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx177960
tested applications
WB, IHC, IF/ICC
Description
ATP-Dependent Translocase ABCB1 (ABCB1) Antibody is a Rabbit Polyclonal antibody against ATP-Dependent Translocase ABCB1 (ABCB1) / Permeability Glycoprotein (Pgp).
Documents del producto
Instrucciones
Data sheet
Product specifications
Category | Primary Antibodies |
Immunogen Target | ATP-Dependent Translocase ABCB1 (ABCB1) |
Host | Rabbit |
Reactivity | Rat |
Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
Clonality | Polyclonal |
Conjugation | Unconjugated |
Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
Size 1 | 100 µl |
Size 2 | 200 µl |
Size 3 | 1 ml |
Form | Liquid |
Tested Applications | WB, IHC, IF/ICC |
Buffer | 0.01 M PBS, pH 7.4, containing 0.02% NaN3, 50% glycerol. |
Availability | Shipped within 5-7 working days. |
Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
Dry Ice | No |
UniProt ID | P43245 |
Alias | ABC20,CD243,CLCS,GP170,MDR1,P-GP,PGY1,p-170 |
Background | Antibody anti-ABCB1 |
Status | RUO |
Note | Concentration: 0.89 mg/ml - |
Descripción
ABCB1, also known as P-glycoprotein, is a well-studied ATP-dependent efflux transporter involved in the transport of a wide range of substrates, including drugs, lipids, and xenobiotics. It is highly expressed in barrier tissues, such as the blood-brain barrier, intestines, liver, and kidneys, where it functions to protect tissues by actively exporting toxic compounds and drugs. ABCB1 plays a crucial role in pharmacokinetics, influencing drug absorption, distribution, and elimination. Overexpression of ABCB1 in cancer cells is a major contributor to multidrug resistance, as it pumps chemotherapeutic agents out of cells, reducing their efficacy. Structurally, ABCB1 contains two transmembrane domains and two ATP-binding domains, which utilize ATP hydrolysis to drive substrate transport. Its pivotal role in drug resistance and detoxification makes it a significant target in cancer therapy and pharmacological research.
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