ATP Binding Cassette Transporter C9 (ABCC9) Antibody (Biotin)
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Description
ABCC9 Antibody (Biotin) is a Rabbit Polyclonal against ABCC9 conjugated to Biotin.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | ATP Binding Cassette Transporter C9 (ABCC9) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Biotin |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O60706 |
| Gene ID | 10060 |
| NCBI Accession | NP_005682.2, NM_005691.3 |
| OMIM | 239850 |
| Alias | ABC37,ATFB12,CANTU,CMD1O,IDMYS,SUR2 |
| Background | Antibody anti-ABCC9 |
| Status | RUO |
Descripción
ATP Binding Cassette Subfamily C Member 9 (ABCC9) encodes the sulfonylurea receptor 2 (SUR2), a key regulatory subunit of K-ATP channels found in cardiac, skeletal muscle, and smooth muscle tissues. These channels link cellular metabolism to electrical activity by sensing intracellular ATP and ADP levels, thereby regulating vascular tone and myocardial contractility. ABCC9 mutations have been associated with various conditions, including Cantu syndrome, characterized by hypertrichosis, osteochondrodysplasia, and cardiac abnormalities. The protein also plays a role in ischemic tolerance by modulating mitochondrial function and protecting tissues from damage during ischemic episodes. Pharmacologically, ABCC9 is a target for potassium channel openers, drugs that induce vasodilation and are used in the management of hypertension and angina. Its involvement in metabolic disorders and vascular diseases underscores its therapeutic significance.
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