ATP Binding Cassette Transporter C5 (ABCC5) Antibody (Biotin)
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Description
ABCC5 Antibody (Biotin) is a Rabbit Polyclonal against ABCC5.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | ATP Binding Cassette Transporter C5 (ABCC5) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Biotin |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O15440 |
| Gene ID | 10057 |
| Alias | ABC33,EST277145,MOAT-C,MOATC |
| Background | Antibody anti-ABCC5 |
| Status | RUO |
Descripción
ATP Binding Cassette Subfamily C Member 5 (ABCC5), also known as multidrug resistance-associated protein 5 (MRP5), plays a crucial role in the transport of various substrates across cellular membranes. This protein is part of the ATP-binding cassette (ABC) transporter family and utilizes ATP hydrolysis to facilitate the export of organic anions and cyclic nucleotides like cGMP and cAMP from cells. ABCC5 is expressed in multiple tissues, including the liver, kidneys, and brain, where it contributes to cellular detoxification and protection against xenobiotics and endogenous metabolites. Furthermore, ABCC5 is implicated in drug resistance, particularly in cancer therapy, by actively exporting chemotherapeutic agents, thereby reducing their intracellular accumulation. Research also suggests its role in regulating vascular smooth muscle tone and platelet aggregation, highlighting its physiological significance beyond drug transport. Polymorphisms in ABCC5 may influence individual variability in drug responses and susceptibility to certain diseases, making it a target of interest for pharmacogenomics.
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