ATP Binding Cassette Transporter C2 (ABCC2) Antibody (FITC)
169€ (20 µg)
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935106861
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name
ATP Binding Cassette Transporter C2 (ABCC2) Antibody (FITC)
category
Primary Antibodies
provider
Abbexa
reference
abx334954
Description
ATP Binding Cassette Transporter C2 (ABCC2) Antibody (FITC) is a Rabbit Polyclonal against ATP Binding Cassette Transporter C2 (ABCC2).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | ATP Binding Cassette Transporter C2 (ABCC2) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | FITC |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q92887 |
| Gene ID | 1244 |
| Alias | ABC30,CMOAT,DJS,MRP2,cMRP |
| Background | Antibody anti-ABCC2 |
| Status | RUO |
Descripción
ABCC2, also known as multidrug resistance-associated protein 2 (MRP2), is an ATP-binding cassette transporter primarily expressed on the apical membrane of hepatocytes, where it plays a vital role in bile secretion and detoxification. ABCC2 mediates the ATP-dependent transport of conjugated bilirubin, xenobiotics, and drug metabolites into bile, contributing to the excretion of potentially harmful compounds. It is also expressed in other tissues, such as the kidney and intestine, where it supports renal and intestinal excretion. Mutations in ABCC2 are associated with Dubin-Johnson syndrome, a rare inherited disorder characterized by impaired bilirubin transport and conjugated hyperbilirubinemia. ABCC2’s role in drug efflux and detoxification makes it a significant player in drug pharmacokinetics, impacting drug absorption, distribution, and elimination.
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