ATP Binding Cassette Transporter C2 (ABCC2) Antibody

Documentos del producto

Especificaciones del producto

Primary Antibodies

Target: ATP Binding Cassette Transporter C2 (ABCC2)

Mouse

Human

WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user.

Monoclonal

Unconjugated

Purified by Protein A and Protein G affinity chromatography.

1 ml

Liquid

WB, IHC, IF/ICC

0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol.

Please enquire.

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

No

ABC30,CMOAT,DJS,MRP2,cMRP

Antibody anti-ABCC2

RUO

THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.

Background

ABCC2, also known as multidrug resistance-associated protein 2 (MRP2), is an ATP-binding cassette transporter primarily expressed on the apical membrane of hepatocytes, where it plays a vital role in bile secretion and detoxification. ABCC2 mediates the ATP-dependent transport of conjugated bilirubin, xenobiotics, and drug metabolites into bile, contributing to the excretion of potentially harmful compounds. It is also expressed in other tissues, such as the kidney and intestine, where it supports renal and intestinal excretion. Mutations in ABCC2 are associated with Dubin-Johnson syndrome, a rare inherited disorder characterized by impaired bilirubin transport and conjugated hyperbilirubinemia. ABCC2’s role in drug efflux and detoxification makes it a significant player in drug pharmacokinetics, impacting drug absorption, distribution, and elimination.