ATP Binding Cassette Transporter B4 (ABCB4) Antibody

Este producto es parte de ABCB - ATP binding cassette subfamily B member
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169€ (20 µg)

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935106861
info@markelab.com
name
ATP Binding Cassette Transporter B4 (ABCB4) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx110010
tested applications
ELISA

Description

ATP Binding Cassette Transporter B4 (ABCB4) Antibody is a Rabbit Polyclonal antibody against ATP Binding Cassette Transporter B4 (ABCB4).

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
ATP Binding Cassette Transporter B4 (ABCB4)
Host
Rabbit
Reactivity
Mouse
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purity
> 95%
Purification
Purified by Protein G.
Size 1
20 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
1 mg
Form
Liquid
Tested Applications
ELISA
Buffer
0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
P21440
Gene ID
18670
Alias
ABC21,GBD1,ICP3,MDR2,MDR2/3,MDR3,PFIC-3,PGY3
Background
Antibody anti-ABCB4
Status
RUO

Descripción

ABCB4, also known as MDR3, is expressed on the canalicular membrane of hepatocytes and plays a pivotal role in bile formation by mediating the ATP-dependent translocation of phosphatidylcholine into bile. Phosphatidylcholine protects bile ducts from the detergent effects of bile salts, ensuring proper bile composition and preventing bile-related liver damage. Mutations in ABCB4 are associated with progressive familial intrahepatic cholestasis type 3 (PFIC3), low phospholipid-associated cholelithiasis (LPAC), and other cholestatic liver diseases. Dysregulation of ABCB4 leads to bile duct injury, inflammation, and fibrosis, ultimately resulting in liver dysfunction. As a critical regulator of bile composition, ABCB4 is a significant focus in the study of liver health and diseases related to bile metabolism.

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