ATP Binding Cassette Subfamily G Member 4 (ABCG4) Antibody
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Description
The protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily and is expressed predominantly in liver tissue. The function has not yet been determined but may involve cholesterol transport. Alternate splice variants have been described but their full length sequences have not been determined.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | ATP Binding Cassette Subfamily G Member 4 (ABCG4) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9H172 |
| Alias | WHITE2 |
| Background | Antibody anti-ABCG4 |
| Status | RUO |
Descripción
ABCG4 is a member of the ATP-binding cassette (ABC) transporter family, subfamily G, primarily expressed in the brain, macrophages, and hematopoietic stem cells. This protein plays a key role in cellular lipid homeostasis, particularly in cholesterol and phospholipid transport. It is involved in maintaining membrane lipid composition and may contribute to processes like neuroprotection and immune cell function. Dysfunction or aberrant regulation of ABCG4 is implicated in lipid-related disorders and neurological diseases. Understanding its precise role is critical for exploring its therapeutic potential in metabolic and neurodegenerative conditions.
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