ATP Binding Cassette Subfamily D Member 1 (ABCD1) Antibody
364€ (100 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
ATP Binding Cassette Subfamily D Member 1 (ABCD1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx230037
tested applications
ELISA, WB
Description
ABCD1 Antibody is a Mouse Monoclonal against ABCD1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | ATP Binding Cassette Subfamily D Member 1 (ABCD1) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | WB: 1/200 - 1/1000, IF/ICC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by Protein A and Protein G affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P33897 |
| Gene ID | 215 |
| OMIM | 300100 |
| Alias | ABC42,ALD,ALDP,AMN,Adrenoleukodystrophy protein |
| Background | Antibody anti-ABCD1 |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
ATP Binding Cassette Transporter D1 (ABCD1), part of the peroxisomal ABC transporter family, facilitates the import of very-long-chain fatty acids (VLCFAs) into peroxisomes for degradation. Mutations in the ABCD1 gene cause X-linked adrenoleukodystrophy (X-ALD), a neurodegenerative disorder characterized by the accumulation of VLCFAs in the central nervous system, adrenal glands, and plasma. ABCD1 dysfunction leads to demyelination, adrenal insufficiency, and progressive neurological decline. The protein is ubiquitously expressed, with high levels in tissues involved in lipid metabolism, including the liver, adrenal glands, and brain. Therapies targeting ABCD1, such as gene therapy and dietary interventions to reduce VLCFA levels, have shown promise in mitigating disease progression. Its essential role in lipid homeostasis highlights its broader relevance in metabolic and peroxisomal disorders.
Related Products
anti- ABCD1 antibody
Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity.
Ver Producto
anti- ABCD1 antibody
Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity.
Ver Producto
anti- ABCD1 antibody
Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity.
Ver Producto