ATP Binding Cassette Subfamily C Member 11 (ABCC11) Antibody
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Description
ABCC11 Antibody is a Rabbit Polyclonal against ABCC11.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | ATP Binding Cassette Subfamily C Member 11 (ABCC11) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 20 µl |
| Size 2 | 50 µl |
| Size 3 | 100 µl |
| Size 4 | 200 µl |
| Size 5 | 1 ml |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q96J66 |
| Gene ID | 85320 |
| NCBI Accession | NP_115972.2, NM_032583.3 |
| OMIM | 117800 |
| Alias | EWWD,MRP8,WW |
| Background | Antibody anti-ABCC11 |
| Status | RUO |
Descripción
ATP-binding cassette subfamily C member 11 (ABCC11), also known as multidrug resistance-associated protein 8 (MRP8), is an ATP-dependent transporter involved in the efflux of various organic anions, including bile acids, cyclic nucleotides, and conjugated steroid hormones. It is highly expressed in apocrine glands, liver, and breast tissue, playing a role in physiological processes like bile acid secretion and earwax type determination. ABCC11 has clinical significance in drug transport and metabolism, with variants linked to differences in drug sensitivity and cancer susceptibility. Mutations in ABCC11 are associated with traits like dry vs. wet earwax and body odor. It has two transmembrane and two nucleotide-binding domains typical of ABC transporters.
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