ATP-Binding Cassette Subfamily B Member 5 (ABCB5) Antibody
416€ (200 µl)
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935106861
info@markelab.com
name
ATP-Binding Cassette Subfamily B Member 5 (ABCB5) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx432262
tested applications
P-ELISA, WB, FCM
Description
ABCB5 Antibody is a Goat Polyclonal antibody against ABCB5.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | ATP-Binding Cassette Subfamily B Member 5 (ABCB5) |
| Host | Goat |
| Reactivity | Human |
| Recommended Dilution | P-ELISA: 1/32000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB, FCM |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 340273 |
| NCBI Accession | NP_848654.3, NP_001157413.1 |
| OMIM | 611785 |
| Alias | ABCB5alphabeta,EST422562 |
| Background | Antibody anti-ABCB5 |
| Status | RUO |
| Note | Concentration: 0.5 mg/ml - |
Descripción
ABCB5 is a transmembrane ATP-binding cassette (ABC) transporter known for its roles in drug resistance, stem cell biology, and tissue repair. It is expressed in a variety of tissues, including melanocytes, the corneal epithelium, and cancer stem cells, particularly in melanoma. ABCB5 functions as a drug efflux pump, actively exporting chemotherapeutic agents out of cells, contributing to multidrug resistance in cancer. It is also a recognized marker of cancer stem cells, promoting tumor growth, metastasis, and resistance to standard therapies. Beyond its role in cancer, ABCB5 has been implicated in wound healing and tissue regeneration due to its expression in progenitor cells in damaged tissues. Structurally, ABCB5 contains transmembrane domains and ATP-binding sites that drive substrate transport through ATP hydrolysis. Dysregulation of ABCB5 is associated with cancer progression, chemoresistance, and impaired tissue repair, making it a promising therapeutic target in oncology and regenerative medicine.
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